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Cystic fibrosis (CF) lungs harbor a complex community of interacting microbes, including pathogens like  Pseudomonas aeruginosa . Meta-taxogenomic analysis based on V5-V6  rrs  PCR products of 52 P. aeruginosa-positive (Pp) and 52 P. aeruginosa-negative (Pn) pooled DNA extracts from CF sputa suggested positive associations between  P .  aeruginosa  and  Stenotrophomonas  and  Prevotella , but negative ones with  Haemophilus ,  Neisseria  and  Burkholderia . Internal Transcribed Spacer analyses (RISA) from individual DNA extracts identified three significant genetic structures within the CF cohorts, and indicated an impact of  P .  aeruginosa . RISA clusters Ip and IIIp contained CF sputa with a  P .  aeruginosa  prevalence above 93%, and of 24.2% in cluster IIp. Clusters Ip and IIIp showed lower RISA genetic diversity and richness than IIp. Highly similar cluster IIp RISA profiles were obtained from two patients harboring isolates of a same  P .  aeruginosa  clone, suggesting convergent evolution in the structure of their microbiota. CF patients of cluster IIp had received significantly less antibiotics than patients of clusters Ip and IIIp but harbored the most resistant  P .  aeruginosa  strains. Patients of cluster IIIp were older than those of Ip. The effects of  P .  aeruginosa  on the RISA structures could not be fully dissociated from the above two confounding factors but several trends in these datasets support the conclusion of a strong incidence of  P .  aeruginosa  on the genetic structure of CF lung microbiota.

Strong incidence of Pseudomonas aeruginosa on bacterial rrs and ITS genetic structures of cystic fibrosis sputa