English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  An increasing rate of respiratory colonization and infection in cystic fibrosis (CF) is caused by fungi of the  Scedosporium apiospermum  species complex or  Lomentospora prolificans  ( Sac-Lp ). These fungi rank second among the filamentous fungi colonizing the CF airways, after  Aspergillus fumigatus . However, the epidemiology, clinical relevance and risk of pulmonary colonization with  Sac-Lp  are rarely understood in CF. The objective of the present prospective multicenter study was to study pathogen distribution and determine association factors of pulmonary  Sac-Lp  colonization in patients with CF.    Material and methods  Clinical, microbiological and laboratory data of 161 patients aged 6–59 years with CF in Germany were analyzed for  Sac-Lp  distribution and association factors. The free statistical software R was utilized to investigate adjusted logistic regression models for association factors.    Results  Of the 161 patients included in the study, 74 (56%) were male. The median age of the study cohort was 23 years (interquartile range 13–32 years). 58 patients of the total cohort (36%) were < 18 years old. Adjusted multivariate regression analysis revealed that  Sac-Lp  colonization was associated with younger age (OR 0.8684, 95%CI: 0.7955–0.9480, p<0.005) and less colonization with  H .  influenzae  (OR 0.0118, 95%CI: 0.0009–0.1585, p<0.001). In addition,  Sac-Lp- colonized patients had more often allergic bronchopulmonary aspergillosis (ABPA) (OR 14.6663, 95%CI: 2.1873–98.3403, p<0.01) and have been colonized more often with the mucoid phenotype of  Pseudomonas aeruginosa  (OR 9.8941, 95%CI: 1.0518–93.0705, p<0.05).    Conclusion  Newly found association of ABPA and  Pseudomonas  revealed new probable risk factors for  Sac-Lp  colonization. Allergy might play a role in inducing immunologic host reactions which lead to a less effective response to species of  Sac-Lp .

plos one

Prospective multicenter German study on pulmonary colonization with Scedosporium /Lomentospora species in cystic fibrosis: Epidemiology and new association factors