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Objective  Depression research has resulted in knowledge about neurobiology, pharmacological strategies and short-term cost-effective treatments. However, more than two-thirds of all depressed patients experience insufficient improvement. Therefore, a better understanding of what patients, carers and professionals perceive as most helpful in the treatment of depression is needed.    Methods  Concept mapping, a mixed-method design, was used to identify the patients (n = 33), carers (n = 22) and professionals (n = 50) perspectives. In six brainstorm sessions, the patients, carers and professionals generated 795 ideas, which were condensed into 55 unique statements. Subsequently, 100 participants prioritized and sorted these statements, which were analysed by multidimensional scaling and cluster analysis and visualized as a two-dimensional map.    Results  The 55 statements were clustered in 10 factors and further grouped into four main-factors (meta-clusters): ‘Professional therapist’, ‘Treatment content’,  ‘ Structured treatment process’ and ‘Treatment organisation’. Patients and carers prioritized ‘Treatment organisation’ higher than professionals, but overall there was considerable agreement about the factors of treatment the participants perceived as most helpful including factors related to the therapeutic relationship and the ‘creation of hope’.    Conclusions  Our study identified factors of depression treatment perceived as helpful according to patients, carers and professionals. Findings suggest that in a scientific era with emphasis on biological psychiatry, not only patients and carers, but also professionals consider  aspecific  factors the most helpful. Further studies might show that factors we found to be helpful in the treatment for depression, can be generalized to mental health treatment in general.

Helpful Factors in the Treatment of Depression from the Patient’s, Carer’s and Professional’s Perspective: A Concept Map Study