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This study aimed to obtain the coding cDNA sequences of  voltage-gated Na   +    channel  ( scn )  α -subunit ( scna ) and  β -subunit ( scnb ) isoforms from, and to quantify their transcript levels in, the main electric organ (EO), Hunter’s EO, Sach’s EO and the skeletal muscle (SM) of the electric eel,  Electrophorus electricus , which can generate both high and low voltage electric organ discharges (EODs). The full coding sequences of two  scna  ( scn4aa  and  scn4ab ) and three  scnb  ( scn1b ,  scn2b  and  scn4b ) were identified for the first time (except  scn4aa ) in  E .  electricus . In adult fish, the  scn4aa  transcript level was the highest in the main EO and the lowest in the Sach’s EO, indicating that it might play an important role in generating high voltage EODs. For  scn4ab /Scn4ab, the transcript and protein levels were unexpectedly high in the EOs, with expression levels in the main EO and the Hunter’s EO comparable to those of  scn4aa . As the key domains affecting the properties of the channel were mostly conserved between Scn4aa and Scn4ab, Scn4ab might play a role in electrogenesis. Concerning  scnb , the transcript level of  scn4b  was much higher than those of  scn1b  and  scn2b  in the EOs and the SM. While the transcript level of  scn4b  was the highest in the main EO, protein abundance of Scn4b was the highest in the SM. Taken together, it is unlikely that Scna could function independently to generate EODs in the EOs as previously suggested. It is probable that different combinations of Scn4aa/Scn4ab and various Scnb isoforms in the three EOs account for the differences in EODs produced in  E .  electricus . In general, the transcript levels of various  scn  isoforms in the EOs and the SM were much higher in adult than in juvenile, and the three EOs of the juvenile fish could be functionally indistinct.

plos one

Voltage-Gated Na+ Channel Isoforms and Their mRNA Expression Levels and Protein Abundance in Three Electric Organs and the Skeletal Muscle of the Electric Eel Electrophorus electricus