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Purpose  This work aims to develop, validate and optimize the radiolabeling of Starch-Based Microparticles (SBMP) by  188 Re and  68 Ga in the form of ready-to-use radiolabeling kits, the ultimate goal being to obtain a unique theranostic vector for the treatment of Hepatocellular Carcinoma.    Methods  Optimal labeling conditions and composition of freeze-dried kits were defined by monitoring the radiochemical purity while varying several parameters.  In vitro  stability studies were carried out, as well as an  in vivo  biodistribution as a preliminary approach with the intra-arterial injection of  68 Ga radiolabeled SBMP into the hepatic artery of DENA-induced rats followed by PET/CT imaging.    Results  Kits were optimized for  188 Re and  68 Ga with high and stable radiochemical purity (>95% and >98% respectively). The  in vivo  preliminary study was successful with more than 95% of activity found in the liver and mostly in the tumorous part.    Conclusion  SBMP are a promising theranostic agent for the Selective Internal Radiation Therapy of Hepatocellular carcinoma.

68Ga and 188Re Starch-Based Microparticles as Theranostic Tool for the Hepatocellular Carcinoma: Radiolabeling and Preliminary In Vivo Rat Studies