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The  Bifibobacterium longum  subsp.  longum   35624  ™  strain (formerly named  Bifidobacterium longum  subsp.  infantis ) is a well described probiotic with clinical efficacy in Irritable Bowel Syndrome clinical trials and induces immunoregulatory effects in mice and in humans. This paper presents (a) the genome sequence of the organism allowing the assignment to its correct subspeciation  longum ; (b) a comparative genome assessment with other  B .  longum  strains and (c) the molecular structure of the  35624  exopolysaccharide (EPS 624 ). Comparative genome analysis of the  35624  strain with other  B .  longum  strains determined that the sub-speciation of the strain is  longum  and revealed the presence of a  35624 -specific gene cluster, predicted to encode the biosynthetic machinery for EPS 624 . Following isolation and acid treatment of the EPS, its chemical structure was determined using gas and liquid chromatography for sugar constituent and linkage analysis, electrospray and matrix assisted laser desorption ionization mass spectrometry for sequencing and NMR. The EPS consists of a branched hexasaccharide repeating unit containing two galactose and two glucose moieties, galacturonic acid and the unusual sugar 6-deoxy-L-talose. These data demonstrate that the  B .  longum   35624  strain has specific genetic features, one of which leads to the generation of a characteristic exopolysaccharide.

Genome Analysis and Characterisation of the Exopolysaccharide Produced by Bifidobacterium longum subsp. longum 35624™