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Purpose  After endoscopic resection (ER) of gastric tumors, eradication of  Helicobacter pylori  ( H .  pylori ) infection is advised to reduce metachronous recurrence. Optimal timing of such therapy (yet to be established) was investigated herein, examining early active and late scarring stages of post-ER iatrogenic ulcers.    Materials and Methods  Analysis included 514 patients who received proton-pump inhibitor (PPI)-based triple therapy for  H .  pylori  eradication after ER for gastric neoplasms between January 2008 and June 2015. Clinicopathologic characteristics, particularly the timing of triple therapy, were used to compare eradication rates, assigning patients to early- (≤2 weeks), intermediate- (2–8 weeks), and late-phase (≥8 weeks) treatment groups.    Results   H .  pylori  eradication rates differed significantly by timing of triple therapy after ER (early, 90.0%; intermediate, 76.2%, late, 72.4%;  p  <.001). However, eradication success rates were not significantly affected by age, smoking, alcohol consumption, preexisting comorbidity, method of ER, size and location of iatrogenic ulcer, and duration of therapeutic regimen. Early initiation of  H .  pylori  eradication was also identified as a significant independent predictor of eradication success in multivariate analysis (Odds ratio = 3.67, 95% CI 2.18–6.16;  p  <.001).    Conclusion  In patients undergoing ER of gastric tumors, early post-ER attempts at eradication of  H .  pylori  offer the best chance of eradication success.

Early Attempts to Eradicate Helicobacter pylori after Endoscopic Resection of Gastric Neoplasm Significantly Improve Eradication Success Rates