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In the present study, we examined the role of indoleamine 2,3-dioxygenase (IDO) in the development of CCl 4 -induced hepatic fibrosis. The liver fibrosis induced by repetitive administration with CCl 4  was aggravated in IDO-KO mice compared to WT mice. In IDO-KO mice treated with CCl 4 , the number of several inflammatory cells and the expression of pro-inflammatory cytokines increased in the liver. In the results, activated hepatic stellate cells (HSCs) and fibrogenic factors on HSCs increased after repetitive CCl 4  administration in IDO-KO mice compared to WT mice. Moreover, the treatment with  l -tryptophan aggravated the CCl 4 -induced hepatic fibrosis in WT mice. Our findings demonstrated that the IDO deficiency enhanced the inflammation in the liver and aggravated liver fibrosis in repetitive CCl 4 -treated mice.

The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice