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Tumor-targeting  Salmonella enterica  serovar Typhimurium A1-R ( Salmonella  A1-R) had strong efficacy on a melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. GFP-expressing  Salmonella  A1-R highly and selectively colonized the PDOX melanoma and significantly suppressed tumor growth ( p  = 0.021). The combination of  Salmonella  A1-R and cisplatinum (CDDP), both at low-dose, also significantly suppressed the growth of the melanoma PDOX (P = 0.001).  Salmonella  A1-R has future clinical potential for combination chemotherapy with CDDP of melanoma, a highly-recalcitrant cancer.

Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model