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LINC00629  and  MIR503HG  are long intergenic non-coding RNAs (lincRNAs) mapped on chromosome X (Xq26), a region enriched for genes associated with human reproduction. Genes highly expressed in normal reproductive tissues and cancers (CT genes) are well known as potential tumor biomarkers. This study aimed to characterize the structure, expression, function and regulation mechanism of  MIR503HG  and  LINC00629  lincRNAs. According to our data,  MIR503HG  expression was almost exclusive to placenta and  LINC00629  was highly expressed in placenta and other reproductive tissues. Further analysis, using a cancer cell lines panel, showed that  MIR503HG and LINC00629  were expressed in 50% and 100% of the cancer cell lines, respectively.  MIR503HG  was expressed predominantly in the nucleus of JEG-3 choriocarcinoma cells. We observed a positively correlated expression between  MIR503HG  and  LINC00629 , and between the lincRNAs and neighboring miRNAs. Also, both  LINC00629  and  MIR503GH  could be negatively regulated by DNA methylation in an indirect way. Additionally, we identified new transcripts for  MIR503HG  and  LINC00629  that are relatively conserved when compared to other primates. Furthermore, we found that overexpression of  MIR503HG2  and the three-exon  LINC00629  new isoforms decreased invasion and migration potential of JEG-3 tumor cell line. In conclusion, our results suggest that lincRNAs  MIR503HG  and  LINC00629  impaired migration and invasion capacities in a choriocarcinoma  in vitro  model, indicating a potential role in human reproduction and tumorigenesis. Moreover, the  MIR503HG  expression pattern found here could indicate a putative new tumor biomarker.

Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line