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A carbapenem-resistant strain of  Pseudomonas aeruginosa , NCGM1984, was isolated in 2012 from a hospitalized patient in Japan. Immunochromatographic assay showed that the isolate was positive for IMP-type metallo-β-lactamase. Complete genome sequencing revealed that NCGM1984 harbored two copies of  bla  IMP-34 , located at different sites on the chromosome. Each  bla  IMP-34  was present in the same structures of the class 1 integrons,  tnpA (ISPa7)- intI1 - qacG - bla  IMP-34 - aac(6')-Ib - qacEdelta1 - sul1 - orf5 - tniBdelta - tniA . The isolate belonged to multilocus sequence typing ST235, one of the international high-risk clones. IMP-34, with an amino acid substitution (Glu126Gly) compared with IMP-1, hydrolyzed all β-lactamases tested except aztreonam, and its catalytic activities were similar to IMP-1. This is the first report of a clinical isolate of an IMP-34-producing  P .  aeruginosa  harboring two copies of  bla  IMP-34  on its chromosome.

A Carbapenem-Resistant Pseudomonas aeruginosa Isolate Harboring Two Copies of blaIMP-34 Encoding a Metallo-β-Lactamase