English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The aim of this study was to genetically characterize clinical isolates from patients diagnosed with  Mycobacterium avium  lung disease and to investigate the clinical significance. Multi-locus sequencing analysis (MLSA) and pattern of insertion sequence analysis of  M .  avium  isolates from 92 Korean patients revealed that all isolates were  M .  avium  subspecies  hominissuis . In  hsp65  sequevar analysis, codes 2, 15, and 16 were most frequently found (88/92) with similar proportions among cases additionally two isolates belonging to code N2 and an unreported code were identified, respectively. In insertion element analysis, all isolates were IS 1311  positive and IS 900  negative. Four of the  M .  avium  subsp.  hominissuis  isolates did not harbor IS 1245  and 1 of the  M .  avium  isolates intriguingly harbored DT1, which is thought to be a  M .  intracellulare -specific element.  M .  avium  subsp.  hominissuis  harboring IS Mav6  is prevalent in Korea. No significant association between clinical manifestation and treatment response has been found in patients with the  hsp65  code type and IS Mav6 , indicating that no specific strain/genotype among  M .  avium  subsp.  hominissuis  organisms was a major source of  M .  avium  lung disease. Interestingly, the presence of IS Mav6  was correlated with greater resistance to moxifloxacin. Conclusively, the genotype of Korean  M .  avium  subsp.  hominissuis  isolates is not a disease determinant responsible for lung disease and specific virulent factors of  M .  avium  subsp.  hominissuis  need to be investigated further.

plos one

Association of ISMav6 with the Pattern of Antibiotic Resistance in Korean Mycobacterium avium Clinical Isolates but No Relevance between Their Genotypes and Clinical Features