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Dogs acquire infections with the  Anaplasmataceae  family pathogens,  E .  canis ,  E .  chaffeensis ,  E .  ewingii ,  A .  platys  and  A .  phagocytophilum  mostly during summer months when ticks are actively feeding on animals. These pathogens are also identified as causing diseases in people. Despite the long history of tick-borne diseases in dogs, much remains to be defined pertaining to the clinical and pathological outcomes of infections with these pathogens. In the current study, we performed experimental infections in dogs with  E .  canis ,  E .  chaffeensis ,  A .  platys  and  A .  phagocytophilum . Animals were monitored for 42 days to evaluate infection-specific clinical, hematological and pathological differences. All four pathogens caused systemic persistent infections detectible throughout the 6 weeks of infection assessment. Fever was frequently detected in animals infected with  E .  canis ,  E .  chaffeensis , and  A .  platys , but not in dogs infected with  A .  phagocytophilum . Hematological differences were evident in all four infected groups, although significant overlap existed between the groups. A marked reduction in packed cell volume that correlated with reduced erythrocytes and hemoglobin was observed only in  E .  canis  infected animals. A decline in platelet numbers was common with  E .  canis ,  A .  platys  and  A .  phagocytophilum  infections. Histopathological lesions in lung, liver and spleen were observed in all four groups of infected dogs; infection with  E .  canis  had the highest pathological scores, followed by  E .  chaffeensis , then  A .  platys  and  A .  phagocytophilum . All four pathogens induced IgG responses starting on day 7 post infection, which was predominantly comprised of IgG2 subclass antibodies. This is the first detailed investigation comparing the infection progression and host responses in dogs after inoculation with four pathogens belonging to the  Anaplasmataceae  family. The study revealed a significant overlap in clinical, hematological and pathological changes resulting from the infections.

Comparative Experimental Infection Study in Dogs with Ehrlichia canis, E. chaffeensis, Anaplasma platys and A. phagocytophilum