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Group V (GV) phospholipase A 2  (PLA 2 ) is a member of the family of secreted PLA 2  (sPLA2) enzymes .  This enzyme has been identified in several organs, including the kidney. However, the physiologic role of GV sPLA 2  in the maintenance of renal function remains unclear. We used mice lacking the gene encoding GV sPLA 2  ( Pla2g5   −/−  ) and wild-type breeding pairs in the experiments. Mice were individually housed in metabolic cages and 48-h urine was collected for biochemical assays. Kidney samples were evaluated for glomerular morphology, renal fibrosis, and expression/activity of the (Na +  + K + )-ATPase α1 subunit. We observed that plasma creatinine levels were increased in  Pla2g5   −/−   mice following by a decrease in creatinine clearance. The levels of urinary protein were higher in  Pla2g5   −/−   mice than in the control group. Markers of tubular integrity and function such as γ-glutamyl transpeptidase, lactate dehydrogenase, and sodium excretion fraction (FE Na  + ) were also increased in  Pla2g5   −/−   mice. The increased FE Na  +  observed in  Pla2g5   −/−   mice was correlated to alterations in cortical (Na +  + K + ) ATPase activity/ expression. In addition, the kidney from  Pla2g5   −/−   mice showed accumulation of matrix in corticomedullary glomeruli and tubulointerstitial fibrosis. These data suggest GV sPLA 2  is involved in the maintenance of tubular cell function and integrity, promoting sodium retention through increased cortical (Na +  + K + )-ATPase expression and activity.

Group V Secretory Phospholipase A2 Is Involved in Tubular Integrity and Sodium Handling in the Kidney