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Across bacterial species, metal binding proteins can serve functions in pathogenesis in addition to regulating metal homeostasis. We have compared and contrasted the activities of zinc (Zn 2+ )-binding lipoproteins AdcA and AdcAII in the  Streptococcus pneumoniae  TIGR4 background. Exposure to Zn 2+ -limiting conditions resulted in delayed growth in a strain lacking AdcAII (ΔAdcAII) when compared to wild type bacteria or a mutant lacking AdcA (ΔAdcA). AdcAII failed to interact with the extracellular matrix protein laminin despite homology to laminin-binding proteins of related streptococci. Deletion of AdcA or AdcAII led to significantly increased invasion of A549 human lung epithelial cells and a trend toward increased invasion  in vivo . Loss of AdcAII, but not AdcA, was shown to negatively impact early colonization of the nasopharynx. Our findings suggest that expression of AdcAII affects invasiveness of  S .  pneumoniae  in response to available Zn 2+  concentrations.

AdcAII of Streptococcus pneumoniae Affects Pneumococcal Invasiveness