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In the yeast  Saccharomyces cerevisiae , cells undergoing sporulation form prospore membranes to surround their meiotic nuclei. The prospore membranes ultimately become the plasma membranes of the new cells. The putative phospholipase Spo1 and the tandem Pleckstrin Homology domain protein Spo71 have previously been shown to be required for prospore membrane development, along with the constitutively expressed Vps13 involved in vacuolar sorting. Here, we utilize genetic analysis, and find that  SPO73  is required for proper prospore membrane shape and, like  SPO71 , is necessary for prospore membrane elongation. Additionally, similar to  SPO71 , loss of  SPO73  partially suppresses  spo1 Δ. Spo73 localizes to prospore membranes and complexes with Spo71. We also find that phosphatidylserine localizes to the prospore membrane. Our results suggest a model where  SPO71  and  SPO73  act in opposition to  SPO1  to form and elongate prospore membranes, while  VPS13  plays a distinct role in prospore membrane development.

SPO73 and SPO71 Function Cooperatively in Prospore Membrane Elongation During Sporulation in Saccharomyces cerevisiae