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White-nose syndrome (WNS), an emerging disease of hibernating bats, has rapidly spread across eastern North America killing millions of bats.  Pseudogymnoascus destructans  ( Pd ), the sole etiologic agent of WNS, is widespread and persistent in bat hibernacula. Control of  Pd  in the affected sites is urgently needed to break the transmission cycle while minimizing any adverse impact on the native organisms. We isolated a novel strain of  Trichoderma polysporum  ( Tp ) from one of the caves at the epicenter of WNS zoonotic. Detailed experimental studies revealed: (1)  Tp  WPM 39143 was highly adapted to grow at temperatures simulating the cave environment (6°C-15°C), (2)  Tp  WPM 39143 restricted  Pd  colony growth in dual culture challenges, (3)  Tp  WPM 39143 caused four logs reduction of  Pd  colony forming units and genome copies in autoclaved soil samples from one of the WNS affected caves, (4)  Tp  WPM 39143 extract showed specific fungicidal activity against  Pd  in disk diffusion assay, but not against closely related fungus  P .  pannorum  ( Pp ), (5)  Tp  WPM 39143 extract retained inhibitory activity after exposure to high temperatures, light and proteinase K, and (6) Inhibitory metabolites in  Tp  WPM 39143 extract comprised of water-soluble, high polarity compounds. These results suggest that  Tp  WPM 39143 is a promising candidate for further evaluation as a biocontrol agent of  Pd  in WNS affected sites.

Novel Trichoderma polysporum Strain for the Biocontrol of Pseudogymnoascus destructans, the Fungal Etiologic Agent of Bat White Nose Syndrome