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Objective  Pulse oximetry, which noninvasively detects the blood flow of peripheral tissue, has achieved widespread clinical use. We have noticed that the better the quality of cardiopulmonary resuscitation (CPR), the better the appearance of pulse oximetry plethysmographic waveform (POP). We investigated whether the area under the curve (AUC) and/or the amplitude (Amp) of POP could be used to monitor the quality of CPR.    Design  Prospective, randomized controlled study.    Setting  Animal experimental center in Peking Union Medical Collage Hospital, Beijing, China.    Subjects  Healthy 3-month-old male domestic swine.    Interventions  34 local pigs were enrolled in this study. After 4 minutes of untreated ventricular fibrillation, animals were randomly assigned into two resuscitation groups: a “low quality” group (with a compression depth of 3cm) and a “high quality” group (with a depth of 5cm). All treatments between the two groups were identical except for the depth of chest compressions. Hemodynamic parameters [coronary perfusion pressure (CPP), partial pressure of end-tidal carbon dioxide (P ET CO 2 )] as well as AUC and Amp of POP were all collected and analyzed.    Measurements and Findings  There were statistical differences between the “high quality” group and the “low quality” group in AUC, Amp, CPP and P ET CO 2  during CPR (P<0.05). AUC, Amp and CPP were positively correlated with P ET CO 2 , respectively (P<0.01). There was no statistical difference between the heart rate calculated according to the POP (F CPR ) and the frequency of mechanical CPR at the 3 rd  minute of CPR. The  F    CPR   was lower than the frequency of mechanical CPR at the 6 th  and the 9 th  minute of CPR.    Conclusions  Both the AUC and Amp of POP correlated well with CPP and P ET CO 2  in animal models. The frequency of POP closely matched the CPR heart rate. AUC and Amp of POP might be potential noninvasive quality monitoring markers for CPR.

Pulse Oximetry: A Non-Invasive, Novel Marker for the Quality of Chest Compressions in Porcine Models of Cardiac Arrest