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Impaired homing and delayed recovery upon hematopoietic stem cell transplantation (HSCT) with hematopoietic stem cells (HSC) derived from umbilical cord blood (UCB) is a major problem. Tracking transplanted cells  in vivo  will be helpful to detect impaired homing at an early stage and allows early interventions to improve engraftment and outcome after transplantation. In this study, we show sufficient intracellular labeling of UCB-derived CD34 +  cells, with  19 F-containing PLGA nanoparticles which were detectable with both flow cytometry and magnetic resonance spectroscopy (MRS). In addition, labeled CD34 +  cells maintain their capacity to proliferate and differentiate, which is pivotal for successful engraftment after transplantation  in vivo . These results set the stage for  in vivo  tracking experiments, through which the homing efficiency of transplanted cells can be studied.

Magnetic Resonance Detection of CD34+ Cells from Umbilical Cord Blood Using a 19F Label