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The present study was mainly conducted to determine whether dietary leucine supplementation could attenuate the decrease of the mucin production in the jejunal mucosa of weaned pigs infected by porcine rotavirus (PRV). A total of 24 crossbred barrows weaned at 21 d of age were assigned randomly to 1 of 2 diets supplemented with 1.00% L-leucine or 0.68% L-alanine (isonitrogenous control) for 17 d. On day 11, all pigs were orally infused PRV or the sterile essential medium. During the first 10 d of trial, dietary leucine supplementation could improve the feed efficiency ( P  = 0.09). The ADG and feed efficiency were impaired by PRV infusion ( P <0.05). PRV infusion also increased mean cumulative score of diarrhea, serum rotavirus antibody concentration and crypt depth of the jejunal mucosa ( P <0.05), and decreased villus height: crypt depth ( P  = 0.07), goblet cell numbers ( P <0.05), mucin 1 and 2 concentrations ( P <0.05) and phosphorylated mTOR level ( P <0.05) of the jejunal mucosa in weaned pigs. Dietary leucine supplementation could attenuate the effects of PRV infusion on feed efficiency ( P  = 0.09) and mean cumulative score of diarrhea ( P  = 0.09), and improve the effects of PRV infusion on villus height: crypt depth ( P  = 0.06), goblet cell numbers ( P <0.05), mucin 1 ( P  = 0.08) and 2 ( P  = 0.07) concentrations and phosphorylated mTOR level ( P  = 0.08) of the jejunal mucosa in weaned pigs. These results suggest that dietary 1% leucine supplementation alleviated the decrease of mucin production and goblet cell numbers in the jejunal mucosa of weaned pigs challenged by PRV possibly via activation of the mTOR signaling.

Dietary Leucine Supplementation Improves the Mucin Production in the Jejunal Mucosa of the Weaned Pigs Challenged by Porcine Rotavirus