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Two 2″-isopropenyl dihydrofuran isoflavonoids ( 1  and  3 ), one 2″-isopropenyl dihydrofuran chromone ( 2 ), as well as 13 known compounds were isolated from the herbs of  Crotalaria albida . Their structures and relative configurations were elucidated via NMR and HRESIMS analyses. The 2″ S absolute configuration of  1  and  2  were deduced by comparing their NOESY spectra with that of  3 , which was determined via single crystal X-ray diffraction (CuKα). The 3R absolute configuration of  1  was determined by CD. Compounds  1 ,  2 , and  3  inhibit the adipocyte differentiation and lipid accumulation of 3T3-L1 through down-regulation of PPAR-γ activity.

Isoflavonoids from Crotalaria albida Inhibit Adipocyte Differentiation and Lipid Accumulation in 3T3-L1 Cells via Suppression of PPAR-γ Pathway