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The clinical applicability of brain oxygenation mapping using the MOBILE (  M  apping of   O  xygen   B  y   I  maging   L  ipids relaxation   E  nhancement) magnetic resonance (MR) technique was assessed in the clinical setting of normal brain and of acute cerebral ischemia as a founding proof-of-concept translational study. Changes in the oxygenation level within healthy brain tissue can be detected by analyzing the spin-lattice proton relaxation (‘ Global T    1    ’ combining water and lipid protons ) because of the paramagnetic properties of molecular oxygen. It was hypothesized that selective measurement of the relaxation of the lipid protons (‘ Lipids T    1    ’ ) would result in enhanced sensitivity of pO 2  mapping because of higher solubility of oxygen in lipids than in water, and this was demonstrated in pre-clinical models using the MOBILE technique. In the present study, 12 healthy volunteers and eight patients with acute (48–72 hours) brain infarction were examined with the same clinical 3T MR system. Both Lipids R 1  (R 1  = 1/T 1 ) and Global R 1  were significantly different in the infarcted area and the contralateral unaffected brain tissue, with a higher statistical significance for Lipids R 1  (median difference: 0.408 s -1 ; p<0.0001) than for Global R 1  (median difference: 0.154 s -1 ; p = 0.027). Both Lipids R 1  and Global R 1  values in the unaffected contralateral brain tissue of stroke patients were not significantly different from the R 1  values calculated in the brain tissue of healthy volunteers. The main limitations of the present prototypic version of the MOBILE sequence are the long acquisition time (4 min), hampering robustness of data in uncooperative patients, and a 2 mm slice thickness precluding accurate measurements in small infarcts because of partial volume averaging effects.

Oxygen Mapping within Healthy and Acutely Infarcted Brain Tissue in Humans Using the NMR Relaxation of Lipids: A Proof-Of-Concept Translational Study