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Bacillus  strains have been widely used as the companion strain of  Ketogulonigenium vulgare  in the process of vitamin C fermentation. Different  Bacillus  strains generate different effects on the growth of  K .  vulgare  and ultimately influence the productivity. First, we identified that  Bacillus endophyticus  Hbe603 was an appropriate strain to cooperate with  K .  vulgare  and the product conversion rate exceeded 90% in industrial vitamin C fermentation. Here, we report the genome sequencing of the  B .  endophyticus  Hbe603 industrial companion strain and speculate its possible advantage in the consortium. The circular chromosome of  B .  endophyticus  Hbe603 has a size of 4.87 Mb with GC content of 36.64% and has the highest similarity with that of  Bacillus megaterium  among all the bacteria with complete genomes. By comparing the distribution of COGs with that of  Bacillus thuringiensis ,  Bacillus cereus  and  B .  megaterium ,  B .  endophyticus  has less genes related to cell envelope biogenesis and signal transduction mechanisms, and more genes related to carbohydrate transport and metabolism, energy production and conversion, as well as lipid transport and metabolism. Genome-based functional studies revealed the specific capability of  B .  endophyticus  in sporulation, transcription regulation, environmental resistance, membrane transportation, extracellular proteins and nutrients synthesis, which would be beneficial for  K .  vulgare . In particular,  B .  endophyticus  lacks the Rap-Phr signal cascade system and, in part, spore coat related proteins. In addition, it has specific pathways for vitamin B12 synthesis and sorbitol metabolism. The genome analysis of the industrial  B .  endophyticus  will help us understand its cooperative mechanism in the  K .  vulgare - Bacillus  strain consortium to improve the fermentation of vitamin C.

Genome Sequence of Bacillus endophyticus and Analysis of Its Companion Mechanism in the Ketogulonigenium vulgare-Bacillus Strain Consortium