English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

For multiple sclerosis, genome wide association studies and follow up studies have identified susceptibility single nucleotide polymorphisms located in or near  CLEC16A  at chromosome 16p13.13, encompassing among others  CIITA ,  DEXI  and  SOCS1  in addition to  CLEC16A . These genetic variants are located in intronic or intergenic regions and display strong linkage disequilibrium with each other, complicating the understanding of their functional contribution and the identification of the direct causal variant(s). Previous studies have shown that multiple sclerosis-associated risk variants in  CLEC16A  act as expression quantitative trait loci for  CLEC16A  itself in human pancreatic β-cells, for  DEXI  and  SOCS1  in thymic tissue samples, and for  DEXI  in monocytes and lymphoblastoid cell lines. Since T cells are major players in multiple sclerosis pathogenesis, we have performed expression analyses of the  CIITA-DEXI-CLEC16A-SOCS1  gene cluster in CD4+ and CD8+ T cells isolated from multiple sclerosis patients and healthy controls. We observed a higher expression of  SOCS1  and  CLEC16A  in CD4+ T cells in samples homozygous for the risk allele of  CLEC16A  rs12927355. Pair-wise linear regression analysis revealed high correlation in gene expression in peripheral T cells of  CIITA ,  DEXI ,  CLEC16A  and  SOCS1 . Our data imply a possible regulatory role for the multiple sclerosis-associated rs12927355 in  CLEC16A .

Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells