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Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of  FTO ’s (Fat Mass Obesity) N6-methyl-adenosine (m 6 A) deaminase activity, thus suggesting a link between obesity-associated diseases and the presence of m 6 A in mRNA. Another catalyst of the sudden rise in mRNA methylation research was the release of mRNA methylomes for human, mouse and  Saccharomyces cerevisiae . However, the molecular function, or functions of this mRNA ‘epimark’ remain to be discovered. There is supportive evidence that m 6 A could be a mark for mRNA degradation due to its binding to YTH domain proteins, and consequently being chaperoned to P bodies. Nonetheless, only a subpopulation of the methylome was found binding to  YTHDF2  in HeLa cells.The model organism  Saccharomyces cerevisiae , has only one YTH domain protein ( Pho92 ,  Mrb1 ), which targets  PHO4  transcripts for degradation under phosphate starvation. However, mRNA methylation is only found under meiosis inducing conditions, and  PHO4  transcripts are apparently non-methylated. In this paper we set out to investigate if m 6 A could function alternatively to being a degradation mark in  S .  cerevisiae ; we also sought to test whether it can be induced under non-standard sporulation conditions. We find a positive association between the presence of m 6 A and message translatability. We also find m 6 A induction following prolonged rapamycin treatment.

Yeast m6A Methylated mRNAs Are Enriched on Translating Ribosomes during Meiosis, and under Rapamycin Treatment