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In this study, we evaluated the interactions between  Candida albicans ,  Candida krusei  and  Candida glabrata  in mixed infections. Initially, these interactions were studied in biofilms formed  in vitro . CFU/mL values of  C .  albicans  were lower in mixed biofilms when compared to the single biofilms, verifying 77% and 89% of  C .  albicans  reduction when this species was associated with  C .  glabrata  and  C .  krusei , respectively. After that, we expanded this study for  in vivo  host models of experimental candidiasis.  G .  mellonella  larvae were inoculated with monotypic and heterotypic  Candida  suspensions for analysis of survival rate and quantification of fungal cells in the haemolymph. In the groups with single infections, 100% of the larvae died within 18 h after infection with  C .  albicans . However, interaction groups achieved 100% mortality after 72 h of infection by  C .  albicans - C .  glabrata  and 96 h of infection by  C .  albicans - C .  krusei .  C .  albicans  CFU/mL values from larvae hemolymph were lower in the interacting groups compared with the monoespecies group after 12 h of infection. In addition, immunosuppressed mice were also inoculated with monotypic and heterotypic microbial suspensions to induce oral candidiasis.  C .  albicans  CFU/mL values recovered from oral cavity of mice were higher in the group with single infection by  C .  albicans  than the groups with mixed infections by  C .  albicans - C .  glabrata  and  C .  albicans - C .  krusei . Moreover, the group with single infection by  C .  albicans  had a higher degree of hyphae and epithelial changes in the tongue dorsum than the groups with mixed infections. We concluded that single infections by  C .  albicans  were more harmful for animal models than mixed infections with non- albicans  species, suggesting that  C .  albicans  establish competitive interactions with  C .  krusei  and  C .  glabrata  during biofilm formation and development of experimental candidiasis.

Competitive Interactions between C. albicans, C. glabrata and C. krusei during Biofilm Formation and Development of Experimental Candidiasis