English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

MicroRNAs play an important role in cancer initiation and development. The aim of this study was to investigate whether polymorphisms in miRNA machinery genes are associated with the development of colorectal cancer (CRC).  RAN  rs14035 CT heterozygotes and T allele carriers (CT + TT) genotypes had lower risk of CRC, while the  DICER1  rs3742330,  DROSHA  rs10719, and  XPO5  rs11077 polymorphisms were not associated with CRC in the full study sample. Specifically, male  RAN  rs14035 CT heterozygotes and  XPO5  rs11077 AA genotype (CT/AA) carriers experienced reduced CRC susceptibility (both colon and rectal). Subgroup analysis demonstrated that the combined  RAN  rs14035 CT + TT genotype was associated with rectal cancer, but not colon cancer. In addition, the  DICER1  rs3742330 AG genotype was associated with a significantly increased risk of colon cancer. Stratified analysis revealed the  RAN  rs14035 combined CT+TT genotype was associated with decreased CRC risk in male patients without diabetes mellitus (DM) and in patients with rectal cancer. In addition, we found the  RAN  rs14035 CC genotype was related to a decreased risk of CRC with respect to tumor size and metabolism of homocysteine and folate. Furthermore, patients diagnosed with hypertension or DM who carried the  DROSHA  rs10719 CC genotype showed increased CRC risk, while the  XPO5  rs11077 AC+CC genotype led to increased CRC risk in patients with hypertension only. Our results indicate variations in  RAN  rs14035,  DICER1  rs3742330,  XPO5  rs11077, and  DROSHA  rs10719 of Korean patients are significantly associated with their risk of CRC.

3’-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population