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This study aimed to analyze the influence of  H .  pylori  infection on insulin resistance and metabolic syndrome (MS) by multivariate analysis of a community-based cohort study. From January 2013 to February 2014,811 subjects were enrolled in a community-based cohort study from the northeastern region of Taiwan. All subjects received a demographic survey and blood tests, including an  H .  pylori  antibody test, liver biochemistry tests, lipid profiles, sugar/insulin levels for Homeostatic model assessment (HOMA-IR index), and measurements of adipokines and inflammatory cytokines. A total of 264 men and 547 women were included in this study. The mean age was 59.2 ± 12.7 years. Subjects seropositive for  H .  pylori  antibodies exhibited higher rates of hypertension, an increased incidence of a HOMA-IR index > 2.5 and a higher level of tumor necrosis factor-α than those without  H .  pylori  antibodies. We found a significant difference in the presence of  H .  pylori  antibodies between subjects with MS and those without MS (76.7% vs. 53.7%, p = 0.007) among subjects < 50 y/o. A HOMA-IR index >2.5,  H .  pylori  antibody presence and leptin were predictors for MS in subjects < 50 y/o. The estimated odds ratio of MS for a subject with  H .  pylori  antibodies was 3.717 (95% CI = 1.086–12.719) times that of a subject without  H .  pylori  antibodies. In addition, no difference in  H .  pylori  antibody status was detected for MS prediction in subjects that were ≧ 50 y/o (p = 0.861). In conclusion, subjects with  H .  pylori  antibodies had a higher incidence of a HOMA-IR >2.5 than those without  H pylori  antibodies. For subjects aged < 50 y/o, the  H .  pylori  antibody was a predictor for MS.

Helicobacter pylori Infection Increases Insulin Resistance and Metabolic Syndrome in Residents Younger than 50 Years Old: A Community-Based Study