English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A complete picture of the evolution of miRNA combinatorial regulation requires the synthesis of information on all miRNAs and their targets.  MiR156  and  miR529  are two combinatorial regulators of  squamosa  promoter binding protein-like (SBP-box) genes. Previous studies have clarified the evolutionary dynamics of their targets; however, there have been no reports on the evolutionary patterns of two miRNA regulators themselves to date. In this study, we investigated the evolutionary differences between these two miRNA families in extant land plants. Our work found that  miR529  precursor, especially of its mature miRNA sequence, has a higher evolutionary rate. Such accelerating evolution of  miR529  has significantly effects on its structural stability, and sequence conservation against existence of itself. By contrast,  miR156  evolves more rapidly in loop region of the stable secondary structure, which may contribute to its functional diversity. Moreover,  miR156  and  miR529  genes have distinct rates of loss after identical duplication events.  MiR529  genes have a higher average loss rate and asymmetric loss rate in duplicated gene pairs, indicating preferred  miR529  gene losses become another predominant mode of inactivation, that are implicated in the contraction of this family. On the contrary, duplicated  miR156  genes have a low loss rate, and could serve as another new source for functional diversity. Taken together, these results provide better insight into understanding the evolutionary divergence of  miR156  and  miR529  family in miRNA combinational regulation network.

Evolutionary Comparison of Two Combinatorial Regulators of SBP-Box Genes, MiR156 and MiR529, in Plants