English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Objectives    Helicobacter pylori  ( H .  pylori ) infection plays an important role in the carcinogenesis and development of gastric cancer. Eradication of  H .  pylori  can effectively reduce the risk of gastric cancer, but the underlying mechanisms are not fully understood. This study aimed to investigate the effect of eradication of  H .  pylori  on the expression levels of FHIT, IL-8 and P73 in the gastric mucosa of first-degree relatives of gastric cancer patients.    Methods  One hundred and thirty-two patients with functional dyspepsia having first-degree relatives with gastric cancer were prospectively recruited in this study. Nine patients presented with  H .  pylori  infection and family histories of gastric cancer, 61 with  H .  pylori  infection and without family histories of gastric cancer, 6 without  H .  pylori  infection and with family histories of gastric cancer, and 56 without  H .  pylori  infection and family histories of gastric cancer. The protein and mRNA expression levels of FHIT, IL-8 and P73 in gastric mucosa of the subjects were detected by immunohistochemical staining and polymerase chain reaction, respectively.    Results  Compared with the patients without  H .  pylori  infection and family histories of gastric cancer, both the protein and mRNA levels of FIHT significantly decreased in patients with  H .  pylori  infection and/or family histories of gastric cancer, and both the protein and mRNA levels of IL-8 significantly increased. After eradication of  H .  pylori , both the protein and mRNA levels of FHIT were significantly higher, and both the protein and mRNA levels of IL-8 were significantly lower. However,  H .  pylori  infection and family histories of gastric cancer had no major effect on P73 expression.    Conclusions  Down-regulation of FHIT and up-regulation of IL-8 may be involved in the pathogenesis of  H .  pylori  infection in the first-degree relatives of gastric cancer patients.

plos one

Effect of Eradication of Helicobacter pylori on Expression Levels of FHIT, IL-8 and P73 in Gastric Mucosa of First-Degree Relatives of Gastric Cancer Patients