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Purpose  To evaluate and compare the prognostic value of Epstein-Barr virus (EBV) DNA and maximal standard uptake values (SUV max  ) of  18 F-fluoro-2-deoxy-D-glucose positron emission tomography ( 18 F-FDG-PET) in subgroups of nasopharyngeal carcinoma (NPC) patients with locoregional or distant recurrence.    Patients and Methods  A total of 194 patients with recurrent NPC (locoregional recurrence: 107, distant recurrence: 87) were enrolled. Patients took evidence of recurrence performed with  18 F-FDG-PET and an EBV DNA test before salvage treatment. Clinical parameters, the status of EBV DNA and the value of SUV max  were used for survival analysis using the Kaplan-Meier method and the Cox proportional hazards regression model.    Results  In the subgroup of patients with locoregional recurrence, patients with SUV max <8.65 had significantly better overall survival (OS) (P=0.005) compared with the patients with SUV max  ≥8.65. However, both elevated EBV DNA load (≥21,100 copies/ml) and distant SUV max  (≥13.55) were significantly associated with worse OS compared with the patients with EBV DNA <21,100 copies/ml or distant SUV max  <13.55 for the subgroup with distant recurrence (P=0.015 and P=0.006, respectively). The predictive ability of EBV DNA was superior to that of SUV max  (P=0.062). Multivariate analysis showed that SUV max  was only an independent prognostic factor for OS in patients with locoregional recurrence (P=0.042), whereas EBV DNA independently predicted OS for the patients with distant recurrence (P=0.007). For those patients with undetectable EBV DNA, SUV max <8.65 was still an independent favorable prognostic factor (P=0.038).    Conclusions  SUV max  is a useful biomarker for predicting OS in nasopharyngeal carcinoma patients with locoregional recurrence or with undetectable EBV DNA. Both distant SUV max  and EBV DNA appear to be independent predictors of OS in patients with distant recurrence; however, the predictive ability of EBV DNA was superior to that of SUV max .

plos one

Different Prognostic Values of Plasma Epstein-Barr Virus DNA and Maximal Standardized Uptake Value of 18F-FDG PET/CT for Nasopharyngeal Carcinoma Patients with Recurrence