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Obesity may result from altered fatty acid (FA) disposal. Altered FA distribution in obese individuals is poorly understood. Lean wild-type C57BL/6J and obese C57BL/6J  ob/ob   mice received an oral dose of [1- 14 C]18:1n-9 (oleic acid), and the radioactivity in tissues was evaluated at various time points. The  14 C concentration decreased rapidly in gastrointestinal tract but gradually increased and peaked at 96 h in adipose tissue, muscle and skin in lean mice. The  14 C concentration was constant in adipose tissue and muscle of obese mice from 4h to 168h.  14 C-label content in adipose tissue was significantly affected by genotype, whereas muscle  14 C-label content was affected by genotype, time and the interaction between genotype and time. There was higher total  14 C retention (47.7%) in obese mice than in lean mice (9.0%) at 168 h ( P <0.05). The  14 C concentrations in the soleus and gastrocnemius muscle were higher in obese mice than in lean mice ( P <0.05). Perirenal adipose tissue contained the highest  14 C content in lean mice, whereas subcutaneous adipose tissue (SAT) had the highest  14 C content and accounted for the largest proportion of total radioactivity among fat depots in obese mice. More lipid radioactivity was recovered as TAG in SAT from obese mice than from lean mice ( P <0.05). Gene expression suggested acyl CoA binding protein and fatty acid binding protein are important for FA distribution in adipose tissue and muscle. The FA distribution in major tissues was altered in  ob/ob  mice, perhaps contributing to obesity. Understanding the disparity in FA disposal between lean and obese mice may reveal novel targets for the treatment and prevention of obesity.

Alterations in Oral [1-14C] 18:1n-9 Distribution in Lean Wild-Type and Genetically Obese (ob/ob) Mice