English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  The purpose of this study was to explore the combined effect of melatonin receptor type 1A ( MTNR1A ) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer.    Methodology and Principal Findings  Three polymorphisms of the  MTNR1A  gene from 618 patients with oral cancer and 560 non-cancer controls were analyzed by real-time polymerase chain reaction (PCR). The CTA haplotype of the studied  MTNR1A  polymorphisms (rs2119882, rs13140012, rs6553010) was related to a higher risk of oral cancer. Moreover,  MTNR1A  gene polymorphisms exhibited synergistic effects of environmental factors (betel quid and tobacco use) on the susceptibility of oral cancer. Finally, oral-cancer patients with betel quid-chewing habit who had T/T allele of  MTNR1A  rs13140012 were at higher risk for developing an advanced clinical stage and lymph node metastasis.    Conclusion  These results support gene-environment interactions of  MTNR1A  polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.

plos one

Interactions between Environmental Factors and Melatonin Receptor Type 1A Polymorphism in Relation to Oral Cancer Susceptibility and Clinicopathologic Development