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The receptor-like kinase SUPPRESSOR OF BIR1, 1 (SOBIR1) functions as a critical regulator in plant immunity. It is required for activation of cell death and defense responses in Arabidopsis  bak1-interacting receptor-like kinase 1 , 1  ( bir1-1 ) mutant plants. Here we report that the ER quality control component UDP-glucose:glycoprotein glucosyltransferase (UGGT) is required for the biogenesis of SOBIR1 and mutations in  UGGT  suppress the spontaneous cell death and constitutive defense responses in  bir1-1 . Loss of function of  STT3a , which encodes a subunit of the oligosaccharyltransferase complex, also suppresses the autoimmune phenotype in  bir1-1 . However, it has no effect on the accumulation of SOBIR1, suggesting that additional signaling components other than SOBIR1 may be regulated by ER quality control. Our study provides clear evidence that ER quality control play critical roles in regulating defense activation in  bir1-1 .

ER Quality Control Components UGGT and STT3a Are Required for Activation of Defense Responses in Bir1-1