English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In the current study, we tested the  in vivo  effects of  Yy1  gene dosage on the  Peg3  imprinted domain with various breeding schemes utilizing two sets of mutant alleles. The results indicated that a half dosage of  Yy1  coincides with the up-regulation of  Peg3  and  Zim1 , suggesting a repressor role of  Yy1  in this imprinted domain. This repressor role of  Yy1  is consistent with the observations derived from previous  in vitro  studies. The current study also provided an unexpected observation that the maternal allele of  Peg3  is also normally expressed, and thus the expression of  Peg3  is bi-allelic in the specific areas of the brain, including the choroid plexus, the PVN (Paraventricular Nucleus) and the SON (Supraoptic Nucleus) of the hypothalamus. The exact roles of the maternal allele of  Peg3  in these cell types are currently unknown, but this new finding confirms the previous prediction that the maternal allele may be functional in specific cell types based on the lethality associated with the homozygotes for several mutant alleles of the  Peg3  locus. Overall, these results confirm the repressor role of  Yy1  in the  Peg3  domain and also provide a new insight regarding the bi-allelic expression of  Peg3  in mouse brain.

Yy1 Gene Dosage Effect and Bi-Allelic Expression of Peg3