English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Objective  The objective of this study was to test the hypothesis that  p53  Arg72Pro polymorphism may contribute to an increased risk of cutaneous melanoma (CM).    Methods  By searching the databases of PubMed, EMBASE, and Web of Science, a total of 8 eligible case-control studies with 1,957 CM cases and 2,887 controls were included in this meta-analysis. Stata software was used to analyze all the statistical data.    Results  The pooled data by a fixed-effects model suggested an increased risk of CM associated with  p53  Arg72Pro polymorphism under the genetic model of Arg/Pro vs. Pro/Pro without heterogeneity (OR Arg/Pro vs. Pro/Pro  = 1.76, 95% CI = 1.55-1.99,  P   heterogeneity  = 0.075). A similar trend was seen in subgroups of hospital-based studies and population-based studies.    Conclusion  Our meta-analysis based on all studies shows that the  p53  Arg72Pro polymorphism may increase individual susceptibility to CM, particularly in Caucasians and could serve as a biomarker to predict the population at high risk of CM.

Increased Risk of Cutaneous Melanoma Associated with p53 Arg72Pro Polymorphism