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ScOpi1p is a well-characterized transcriptional repressor and master regulator of inositol and phospholipid biosynthetic genes in the baker’s yeast  Saccharomyces cerevisiae . An ortholog has been shown to perform a similar function in the pathogenic fungus  Candida glabrata , but with the distinction that CgOpi1p is essential for growth in this organism. However, in the more distantly related yeast  Yarrowia lipolytica , the  OPI1  homolog was not found to regulate inositol biosynthesis, but alkane oxidation. In  Candida albicans , the most common cause of human candidiasis, its Opi1p homolog, CaOpi1p, has been shown to complement a  S. cerevisiae opi1∆  mutant for inositol biosynthesis regulation when heterologously expressed, suggesting it might serve a similar role in this pathogen. This was tested in the pathogen directly in this report by disrupting the  OPI1  homolog and examining its phenotypes. It was discovered that the  OPI1  homolog does not regulate  INO1  expression in  C. albicans , but it does control  SAP2  expression in response to bovine serum albumin containing media. Meanwhile, we found that CaOpi1 represses filamentous growth at lower temperatures (30°C) on agar, but not in liquid media. Although, the mutant does not affect virulence in a mouse model of systemic infection, it does affect virulence in a rat model of vaginitis. This may be because Opi1p regulates expression of the  SAP2  protease, which is required for rat vaginal infections.

Candida albicans OPI1 Regulates Filamentous Growth and Virulence in Vaginal Infections, but Not Inositol Biosynthesis