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Background  Robust malaria vector surveillance is essential for optimally selecting and targeting vector control measures. Sixty-two vector surveillance sites were established between 2005 and 2008 by the national malaria surveillance program in China to measure  Anopheles sinensis  human biting rates. Using these data to determine the primary ecological drivers of malaria vector human biting rates in malaria epidemic-prone regions of China will allow better targeting of vector control resources in space and time as the country aims to eliminate malaria.    Methods  We analyzed data from 62 malaria surveillance sentinel sites from 2005 to 2008. Linear mixed effects models were used to identify the primary ecological drivers for  Anopheles sinensis  human biting rates as well as to explore the spatial-temporal variation of relevant factors at surveillance sites throughout China.    Results  Minimum semimonthly temperature ( β  = 2.99; 95% confidence interval (CI) 2.07- 3.92), enhanced vegetation index ( β  =1.07; 95% CI 0.11–2.03), and paddy index (the percentage of rice paddy field in the total cultivated land area of each site) ( β  = 0.86; 95% CI 0.17–1.56) were associated with greater  An. Sinensis  human biting rates, while increasing distance to the nearest river was associated with lower  An. Sinensis  human biting rates ( β  = −1.47; 95% CI −2.88, −0.06). The temporal variation (σ   t  0   2=    1.35) in biting rates was much larger than the spatial variation (σ   s  0   2=    0.83), with 19.3% of temporal variation attributable to differences in minimum temperature and enhanced vegetation index and 16.9% of spatial variance due to distance to the nearest river and the paddy index.    Discussion  Substantial spatial-temporal variation in  An. Sinensis  human biting rates exists in malaria epidemic-prone regions of China, with minimum temperature and enhanced vegetation index accounting for the greatest proportion of temporal variation and distance to nearest river and paddy index accounting for the greatest proportion of spatial variation amongst observed ecological drivers.    Conclusions  Targeted vector control measures based on these findings can support the ongoing malaria elimination efforts in China more effectively.

Spatial-Temporal Variation and Primary Ecological Drivers of Anopheles sinensis Human Biting Rates in Malaria Epidemic-Prone Regions of China