English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Secondary metabolites (SMs) produced by  Aspergillus  have been extensively studied for their crucial roles in human health, medicine and industrial production. However, the resulting information is almost exclusively derived from a few model organisms, including  A. nidulans  and  A. fumigatus , but little is known about rare pathogens. In this study, we performed a genomics based discovery of SM biosynthetic gene clusters in  Aspergillus ustus , a rare human pathogen. A total of 52 gene clusters were identified in the draft genome of  A. ustus  3.3904, such as the sterigmatocystin biosynthesis pathway that was commonly found in  Aspergillus  species. In addition, several SM biosynthetic gene clusters were firstly identified in  Aspergillus  that were possibly acquired by horizontal gene transfer, including the  vrt  cluster that is responsible for viridicatumtoxin production. Comparative genomics revealed that  A. ustus  shared the largest number of SM biosynthetic gene clusters with  A. nidulans , but much fewer with other  Aspergilli  like  A. niger  and  A. oryzae . These findings would help to understand the diversity and evolution of SM biosynthesis pathways in genus  Aspergillus , and we hope they will also promote the development of fungal identification methodology in clinic.

A Genomics Based Discovery of Secondary Metabolite Biosynthetic Gene Clusters in Aspergillus ustus