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Background  Oxidative stress genes are related to cancer development and treatment response. In this study, we aimed to determine the predictive and prognostic roles of oxidative stress-related genetic polymorphisms in metastatic gastric cancer (MGC) patients treated with chemotherapy.    Methods  In this retrospective study, we genotyped nine oxidative stress-related single nucleotide polymorphisms (SNPs) in  NQO1 ,  SOD2 ,  SOD3 ,  PON1 ,  GSTP1 ,  GSTT1 , and  NOS3  (rs1800566, rs10517, rs4880, rs1799895, rs662, rs854560, rs1695, rs2266637, rs1799983, respectively) in 108 consecutive MGC patients treated with epirubicin, oxaliplatin, and 5-fluorouracil (EOF) regimen as the first-line chemotherapy and analyzed the association between the genotypes and the disease control rate (DCR), progression-free survival (PFS), and overall survival (OS).    Results  We found that, in addition to a lower pathological grade ( p  = 0.017),  NQO1  rs1800566 CT/TT genotype was an independent predictive factor of poor PFS (hazard ratio [HR] = 1.97, 95% confidence interval [CI] = 1.23–3.16;  p  = 0.005).  PON1  rs662 AA/AG genotype was significantly associated with poor OS (HR = 1.95, 95% CI = 1.07–3.54;  p  = 0.029). No associations were detected between the nine SNPs and DCR.    Conclusions    NQO1  rs1800566 is an independent predictive factor of PFS for MGC patients treated with EOF chemotherapy, and  PON1  rs662 is a noteworthy prognostic factor of OS. Information on oxidative stress-related genetic variants may facilitate optimization of individualized chemotherapy in clinical practice.

plos one

Oxidative Stress-Related Genetic Polymorphisms Are Associated with the Prognosis of Metastatic Gastric Cancer Patients Treated with Epirubicin, Oxaliplatin and 5-Fluorouracil Combination Chemotherapy