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Copyright: 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Figure 4. Experimental validation of model’s predictions shows that import of some decay factors is independent of Xrn1p exonuclease activity. XRN1 (WT) PAB1-GFP xpo1-1, mex67-5 cells, or xpo1-1, mex67-5, Dxrn1 cells expressing xrn1D208A-GFP and RFP fusion of the indicated DFs were proliferated at 24uC and then shifted to 37uC for 1 h; images were taken as previously described [10]. (A) Representative images of WT cells expressing the indicated proteins after 1h incubation at 37uC. Pab1-GFP, whose export is dependent on Xpo1p and Mex67p, serves as a nuclear marker, as described in [10]. Arrows point at examples of nuclei carrying both fluorescent proteins. All factors were cytoplasmic at 24uC ([10] and not shown) (B) Percentage of cells with nuclear localization of the indicated DF was determined, as described previously [10]. Mean values 6 SD are shown. P-values of any pairwise difference that was ,0.05 is indicated. doi:10.1371/journal.pone.0107085.g004

Correction: Conceptual Modeling of mRNA Decay Provokes New Hypotheses