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Cryptococcus gattii  is unique among human pathogenic fungi with specialized ecological niche on trees. Since leaves concentrate CO 2 , we investigated the role of this gaseous molecule in  C. gattii  biology and virulence. We focused on the genetic analyses of β-carbonic anhydrase (β-CA) encoded by  C. gattii CAN1  and  CAN2  as later is critical for CO 2  sensing in a closely related pathogen  C. neoformans . High CO 2  conditions induced robust development of monokaryotic hyphae and spores in  C. gattii . Conversely, high CO 2  completely repressed hyphae development in sexual mating. Both  CAN1  and  CAN2  were dispensable for CO 2  induced morphogenetic transitions. However,  C. gattii CAN2  was essential for growth in ambient air similar to its reported role in  C. neoformans . Both  can1  and  can2  mutants retained full pathogenic potential  in vitro  and  in vivo . These results provide insight into  C. gattii  adaptation for arboreal growth and production of infectious propagules by β-CA independent mechanism(s).

plos one

Carbon Dioxide is a Powerful Inducer of Monokaryotic Hyphae and Spore Development in Cryptococcus gattii and Carbonic Anhydrase Activity is Dispensable in This Dimorphic Transition