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Although several circadian rhythms have been described in  C. elegans , its molecular clock remains elusive. In this work we employed a novel bioinformatic approach, applying probabilistic methodologies, to search for circadian clock proteins of several of the best studied circadian model organisms of different taxa ( Mus musculus, Drosophila melanogaster, Neurospora crassa, Arabidopsis thaliana  and  Synechoccocus elongatus ) in the proteomes of  C. elegans  and other members of the  phylum Nematoda . With this approach we found that the  Nematoda  contain proteins most related to the core and accessory proteins of the insect and mammalian clocks, which provide new insights into the nematode clock and the evolution of the circadian system.

Potential Conservation of Circadian Clock Proteins in the phylum Nematoda as Revealed by Bioinformatic Searches