English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Helicobacter pylori  ( H. pylori ) is a major gastric pathogen that has been associated with humans for more than 60,000 years.  H. pylori  causes different gastric diseases including dyspepsia, ulcers and gastric cancers. Disease development depends on several factors including the infecting  H. pylori  strain, environmental and host factors. Another factor that might influence  H. pylori  colonization and diseases is the gastric microbiota that was overlooked for long because of the belief that human stomach was a hostile environment that cannot support microbial life. Once established,  H. pylori  mainly resides in the gastric mucosa and interacts with the resident bacteria. How these interactions impact on  H. pylori -caused diseases has been poorly studied in human. In this study, we analyzed the interactions between  H. pylori  and two bacteria,  Streptocccus mitis  and  Lactobacillus fermentum  that are present in the stomach of both healthy and gastric disease human patients. We have found that  S. mitis  produced and released one or more diffusible factors that induce growth inhibition and coccoid conversion of  H. pylori  cells. In contrast, both  H. pylori  and  L. fermentum  secreted factors that promote survival of  S. mitis  during the stationary phase of growth. Using a metabolomics approach, we identified compounds that might be responsible for the conversion of  H. pylori  from spiral to coccoid cells. This study provide evidences that gastric bacteria influences  H. pylori  physiology and therefore possibly the diseases this bacterium causes.

Streptococcus mitis Induces Conversion of Helicobacter pylori to Coccoid Cells during Co-Culture In Vitro