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Background  Higher insulin-like growth factor (IGF)-1 and lower IGF binding protein (BP)-3 levels have been associated with higher commoncancer risk, including breast cancer. Dietary factors, genetic polymorphisms, and the combination of both may influence circulating IGF-1 and IGFBP-3 serum concentrations.    Methods  From September 2011 to July 2012, we collected demographic, reproductive and dietary data on 143 women (≥40 years). We genotyped  IGF-1  rs1520220 and  IGFBP-3  rs2854744 and measured circulating IGF-1 and IGFBP-3 levels in serum. Covariance analyses were used to estimate the associations of serum levels of IGF-1 and IGFBP-3, and the molar ratio of IGF-1to IGFBP-3 with  IGF-1  rs1520220 and  IGFBP-3  rs2854744 genotypes. We subsequently assessed the combined influence of genetics and diet (daily intake of protein, fat and soy isoflavones) on IGF-1 and IGFBP-3 levels.    Results  Among women aged less than 50 years, circulating IGF-1 serum levels were significantly lower for those with CC genotype for  IGF-1  rs1520220 than levels for those with the GC or GG genotypes (in recessive model:  P  = 0.007).In gene-diet analyses among these women, we found carrying CC genotype for  IGF-1  rs1520220 and high soy isoflavone intake tend to be associated with lower circulating IGF-1 levels synthetically ( P  = 0.002). Women with GG or GC genotypes for  IGF-1  rs1520220 and with low intake of soy isoflavones had the highest levels of circulating IGF-1 (geometric mean [95% CI]: 195 [37, 1021] µg/L). Comparatively, women with both the CC genotype and high soy intake had the lowest levels of circulating IGF-1 (geometric mean [95% CI]: 120 [38,378] µg/L).    Conclusions  IGF-1 serum levels are significantly lower among women with the CC genotype for  IGF-1 -rs1520220. High soy isoflavone intake may interact with carrying CC genotype for  IGF-1 -rs1520220 to lower women's serum IGF-1 levels more.

Genetic and Dietary Determinants of Insulin-Like Growth Factor (IGF)-1 and IGF Binding Protein (BP)-3 Levels among Chinese Women