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Background  A reduction of dopamine release or D 2  receptor blockade in the terminal fields of the mesolimbic system clearly reduces conditioned fear. Injections of haloperidol, a preferential D 2  receptor antagonist, into the inferior colliculus (IC) enhance the processing of unconditioned aversive information. However, a clear characterization of the interplay of D 2  receptors in the mediation of unconditioned and conditioned fear is still lacking.    Methods  The present study investigated the effects of intra-IC injections of the D 2  receptor-selective antagonist sulpiride on behavior in the elevated plus maze (EPM), auditory-evoked potentials (AEPs) to loud sounds recorded from the IC, fear-potentiated startle (FPS), and conditioned freezing.    Results  Intra-IC injections of sulpiride caused clear proaversive effects in the EPM and enhanced AEPs induced by loud auditory stimuli. Intra-IC sulpiride administration did not affect FPS or conditioned freezing.    Conclusions  Dopamine D 2 -like receptors of the inferior colliculus play a role in the modulation of unconditioned aversive information but not in the fear-potentiated startle response.

Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus