English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Purpose  To characterize intermediate and high-risk prostate carcinomas with measurements of standardized uptake values (SUVs) and apparent diffusion coefficient (ADC) values by means of simultaneous [ 18 F] choline PET/MRI.    Materials and Methods  35 patients with primary prostate cancer underwent simultaneous [ 18 F] choline PET/MRI. From these, 21 patients with an intermediate and high risk constellation who were not under ongoing hormonal therapy were included. Altogether 32 tumor lesions with a focal uptake of [ 18 F] choline could be identified. Average ADC values (ADC aver ) minimum ADC values (ADC min ) as well as maximum and mean SUVs (SUV max , SUV mean ) of tumor lesions were assessed with volume-of-interest (VOI) and Region-of-interest (ROI) measurements. As a reference, also ADC aver,  ADC min  and SUV max  and SUV mean  of non-tumorous prostate tissue were measured. Statistical analysis comprised calculation of descriptive parameters and calculation of Pearson’s product moment correlations between ADC values and SUVs of tumor lesions.    Results  Mean ADC aver  and ADC min  of tumor lesions were 0.94±0.22×10 −3  mm 2 /s and 0.65±0.21×10 −3  mm 2 /s, respectively. Mean SUV max  and SUV mean  of tumor lesions were 6.3±2.3 and 2.6±0.8, respectively. These values were in each case significantly different from the reference values (p<0.001). There was no significant correlation between the measured SUVs and ADC values (SUV max  vs. ADC aver : R = −0.24, p = 0.179; SUV max  vs. ADC min : R = −0.03, p = 0.877; SUV mean  vs. ADC aver : R = −0.27, p = 0.136; SUV mean  vs. ADC min : R = −0.08, p = 0.679).    Conclusion  Both SUVs and ADC values differ significantly between tumor lesions and healthy tissue. However, there is no significant correlation between these two parameters. This might be explained by the fact that SUVs and ADC values characterize different parts of tumor biology.

Combined PET Imaging and Diffusion-Weighted Imaging of Intermediate and High-Risk Primary Prostate Carcinomas with Simultaneous [18F] Choline PET/MRI