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Hydrogen sulfide (H 2 S) has been revealed to be a signal molecule with second messenger action in the somatic cells of many tissues, including the reproductive tract. The aim of this study was to address how exogenous H 2 S acts on the meiotic maturation of porcine oocytes, including key maturation factors such as MPF and MAPK, and cumulus expansion intensity of cumulus-oocyte complexes. We observed that the H 2 S donor, Na 2 S, accelerated oocyte  in vitro  maturation in a dose-dependent manner, following an increase of MPF activity around germinal vesicle breakdown. Concurrently, the H 2 S donor affected cumulus expansion, monitored by hyaluronic acid production. Our results suggest that the H 2 S donor influences oocyte maturation and thus also participates in the regulation of cumulus expansion. The exogenous H 2 S donor apparently affects key signal pathways of oocyte maturation and cumulus expansion, resulting in faster oocyte maturation with little need of cumulus expansion.

Dual Effects of Hydrogen Sulfide Donor on Meiosis and Cumulus Expansion of Porcine Cumulus-Oocyte Complexes