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For several years, DEAD box RNA helicase Vasa (DDX4) has been used as a bona fide germline marker in different organisms.  C. elegans  VBH-1 is a close homolog of the Vasa protein, which plays an important role in gametogenesis, germ cell survival and embryonic development. Here, we show that VBH-1 protects nematodes from heat shock and oxidative stress. Using the germline-defective mutant  glp-4(bn2)  we found that a potential somatic expression of  vbh-1  might be important for stress survival. We also show that the VBH-1 paralog LAF-1 is important for stress survival, although this protein is not redundant with its counterpart. Furthermore, we observed that the mRNAs of the heat shock proteins  hsp-1  and  sip-1  are downregulated when  vbh-1  or  laf-1  are silenced. Previously, we reported that in  C. elegans , VBH-1 was primarily expressed in P granules of germ cells and in the cytoplasm of all blastomeres. Here we show that during stress, VBH-1 co-localizes with CGH-1 in large aggregates in the gonad core and oocytes; however, VBH-1 aggregates do not overlap with CGH-1 foci in early embryos under the same conditions. These data demonstrate that, in addition to the previously described role for this protein in the germline, VBH-1 plays an important role during the stress response in  C. elegans  through the potential direct or indirect regulation of stress response mRNAs.

The DEAD Box RNA Helicase VBH-1 Is a New Player in the Stress Response in C. elegans