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The heat shock protein of  Toxoplasma gondii  ( Tg HSP70) is a parasite virulence factor that is expressed during  T. gondii  stage conversion. To verify the effect of dexamethasone (DXM)-induced infection reactivation in the  Tg HSP70-specific humoral immune response and the presence of the protein in the mouse brain, we produced recombinant  Tg HSP70 and anti- Tg HSP70 IgY antibodies to detect the protein, the specific antibody and levels of immune complexes (ICs) systemically, as well as the protein in the brain of resistant (BALB/c) and susceptible (C57BL/6) mice. It was observed higher  Tg HSP70-specific antibody titers in serum samples of BALB/c compared with C57BL/6 mice. However, the susceptible mice presented the highest levels of  Tg HSP70 systemically and no detection of specific ICs. The DXM treatment induced increased parasitism and lower inflammatory changes in the brain of C57BL/6, but did not interfere with the cerebral parasitism in BALB/c mice. Additionally, DXM treatment decreased the serological  Tg HSP70 concentration in both mouse lineages. C57BL/6 mice presented high expression of  Tg HSP70 in the brain with the progression of infection and under DXM treatment. Taken together, these data indicate that the  Tg HSP70 release into the bloodstream depends on the death of the parasites mediated by the host immune response, whereas the increased  Tg HSP70 expression in the brain depends on the multiplication rate of the parasite.

plos one

Toxoplasma gondii 70 kDa Heat Shock Protein: Systemic Detection Is Associated with the Death of the Parasites by the Immune Response and Its Increased Expression in the Brain Is Associated with Parasite Replication